Department   Research Institutes and Facilities, Research Institutes and Facilities
   Position   Associate Professor (Fixed Term)
Article types Original article
Language English
Peer review Peer reviewed
Title [Cancer stromal cells influence on the tumor angiogenic pattern].
Journal Formal name:Gan to kagaku ryoho. Cancer & chemotherapy
Abbreviation:Gan To Kagaku Ryoho
ISSN code:03850684/03850684
Domestic / ForeginDomestic
Volume, Issue, Page 35(12),pp.2250-2
Author and coauthor Kitahara Shuji, Itagaki Hiroko, Ezaki Taichi
Publication date 2008/11
Summary Since the progression and metastasis of solid tumors depend on their local microcirculation, we sought to characterize the tumor angiogenesis three-dimensionally in a highly metastatic mouse melanoma model, B16BL6 melanoma injected with Matrigel into syngeneic C57BL/6 mice by using confocal laser scanning microscopy and transmission electron microscopy. We found that B16 melanoma within Matrigel grew significantly quicker than B16 melanoma alone and was accompanied by altered tumor angiogenesis and avascular area. We characterized the unique patterns of avascular area by using confocal laser-scanning microscopy and transmission electron microscopy.
PMID 19106586