KITAHARA Shuji    Department   Research Institutes and Facilities, Research Institutes and Facilities    Position   Associate Professor (Fixed Term)
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	[Cancer stromal cells influence on the tumor angiogenic pattern].
Journal	Formal name：Gan to kagaku ryoho. Cancer & chemotherapy Abbreviation：Gan To Kagaku Ryoho ISSN code：03850684/03850684
Domestic / Foregin	Domestic
Volume, Issue, Page	35(12),pp.2250-2
Author and coauthor	Kitahara Shuji, Itagaki Hiroko, Ezaki Taichi
Publication date	2008/11
Summary	Since the progression and metastasis of solid tumors depend on their local microcirculation, we sought to characterize the tumor angiogenesis three-dimensionally in a highly metastatic mouse melanoma model, B16BL6 melanoma injected with Matrigel into syngeneic C57BL/6 mice by using confocal laser scanning microscopy and transmission electron microscopy. We found that B16 melanoma within Matrigel grew significantly quicker than B16 melanoma alone and was accompanied by altered tumor angiogenesis and avascular area. We characterized the unique patterns of avascular area by using confocal laser-scanning microscopy and transmission electron microscopy.
PMID	19106586