Department   Research Institutes and Facilities, Research Institutes and Facilities
   Position   Associate Professor (Fixed Term)
Article types Original article
Language English
Peer review Peer reviewed
Title Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice.
Journal Formal name:Scie
ISSN code:(1095-9203)0036-8075(Linking)
Domestic / ForeginForegin
Volume, Issue, Page 359(6382),pp.1403-1407
Author and coauthor Pereira Ethel R, Kedrin Dmitriy, Seano Giorgio, Gautier Olivia, Meijer Eelco F J, Jones Dennis, Chin Shan-Min, Kitahara Shuji, Bouta Echoe M, Chang Jonathan, Beech Elizabeth, Jeong Han-Sin, Carroll Michael C, Taghian Alphonse G, Padera Timothy P
Publication date 2018/03
Summary Lymph node metastases in cancer patients are associated with tumor aggressiveness, poorer prognoses, and the recommendation for systemic therapy. Whether cancer cells in lymph nodes can seed distant metastases has been a subject of considerable debate. We studied mice implanted with cancer cells (mammary carcinoma, squamous cell carcinoma, or melanoma) expressing the photoconvertible protein Dendra2. This technology allowed us to selectively photoconvert metastatic cells in the lymph node and trace their fate. We found that a fraction of these cells invaded lymph node blood vessels, entered the blood circulation, and colonized the lung. Thus, in mouse models, lymph node metastases can be a source of cancer cells for distant metastases. Whether this mode of dissemination occurs in cancer patients remains to be determined.
DOI 10.1126/science.aal3622
PMID 29567713