キタハラ　シユウジ   KITAHARA Shuji   北原　秀治    所属   研究施設 研究施設    職種   特任准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice.
掲載誌名	正式名：Scie 略　 称：Science ISSNコード：(1095-9203)0036-8075(Linking)
掲載区分	国外
巻・号・頁	359(6382),pp.1403-1407
著者・共著者	Pereira Ethel R, Kedrin Dmitriy, Seano Giorgio, Gautier Olivia, Meijer Eelco F J, Jones Dennis, Chin Shan-Min, Kitahara Shuji, Bouta Echoe M, Chang Jonathan, Beech Elizabeth, Jeong Han-Sin, Carroll Michael C, Taghian Alphonse G, Padera Timothy P
発行年月	2018/03
概要	Lymph node metastases in cancer patients are associated with tumor aggressiveness, poorer prognoses, and the recommendation for systemic therapy. Whether cancer cells in lymph nodes can seed distant metastases has been a subject of considerable debate. We studied mice implanted with cancer cells (mammary carcinoma, squamous cell carcinoma, or melanoma) expressing the photoconvertible protein Dendra2. This technology allowed us to selectively photoconvert metastatic cells in the lymph node and trace their fate. We found that a fraction of these cells invaded lymph node blood vessels, entered the blood circulation, and colonized the lung. Thus, in mouse models, lymph node metastases can be a source of cancer cells for distant metastases. Whether this mode of dissemination occurs in cancer patients remains to be determined.
DOI	10.1126/science.aal3622
PMID	29567713