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KITAHARA Shuji
Department Research Institutes and Facilities, Research Institutes and Facilities Position Associate Professor (Fixed Term) |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice. |
| Journal | Formal name：Hepatology (Baltimore, Md.) Abbreviation：Hepatology ISSN code：(1527-3350)0270-9139(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 61(5),pp.1591-602 |
| Author and coauthor | Chen Yunching, Ramjiawan Rakesh R, Reiberger Thomas, Ng Mei R, Hato Tai, Huang Yuhui, Ochiai Hiroki, Kitahara Shuji, Unan Elizabeth C, Reddy Tejaswini P, Fan Christopher, Huang Peigen, Bardeesy Nabeel, Zhu Andrew X, Jain Rakesh K, Duda Dan G |
| Publication date | 2015/05 |
| Summary | Anti-PD-1 treatment can boost antitumor immune responses in HCC models; when used in combination with sorafenib, anti-PD-1 immunotherapy shows efficacy only with concomitant targeting of the hypoxic and immunosuppressive microenvironment with agents such as CXCR4 inhibitors. |
| DOI | 10.1002/hep.27665 |
| PMID | 25529917 |