Department   Research Institutes and Facilities, Research Institutes and Facilities
   Position   Associate Professor (Fixed Term)
Article types Original article
Language English
Peer review Peer reviewed
Title CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice.
Journal Formal name:Hepatology (Baltimore, Md.)
ISSN code:(1527-3350)0270-9139(Linking)
Domestic / ForeginForegin
Volume, Issue, Page 61(5),pp.1591-602
Author and coauthor Chen Yunching, Ramjiawan Rakesh R, Reiberger Thomas, Ng Mei R, Hato Tai, Huang Yuhui, Ochiai Hiroki, Kitahara Shuji, Unan Elizabeth C, Reddy Tejaswini P, Fan Christopher, Huang Peigen, Bardeesy Nabeel, Zhu Andrew X, Jain Rakesh K, Duda Dan G
Publication date 2015/05
Summary Anti-PD-1 treatment can boost antitumor immune responses in HCC models; when used in combination with sorafenib, anti-PD-1 immunotherapy shows efficacy only with concomitant targeting of the hypoxic and immunosuppressive microenvironment with agents such as CXCR4 inhibitors.
DOI 10.1002/hep.27665
PMID 25529917