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キタハラ シユウジ
KITAHARA Shuji
北原 秀治 所属 研究施設 研究施設 職種 特任准教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice. |
| 掲載誌名 | 正式名：Hepatology (Baltimore, Md.) 略 称：Hepatology ISSNコード：(1527-3350)0270-9139(Linking) |
| 掲載区分 | 国外 |
| 巻・号・頁 | 61(5),pp.1591-602 |
| 著者・共著者 | Chen Yunching, Ramjiawan Rakesh R, Reiberger Thomas, Ng Mei R, Hato Tai, Huang Yuhui, Ochiai Hiroki, Kitahara Shuji, Unan Elizabeth C, Reddy Tejaswini P, Fan Christopher, Huang Peigen, Bardeesy Nabeel, Zhu Andrew X, Jain Rakesh K, Duda Dan G |
| 発行年月 | 2015/05 |
| 概要 | Anti-PD-1 treatment can boost antitumor immune responses in HCC models; when used in combination with sorafenib, anti-PD-1 immunotherapy shows efficacy only with concomitant targeting of the hypoxic and immunosuppressive microenvironment with agents such as CXCR4 inhibitors. |
| DOI | 10.1002/hep.27665 |
| PMID | 25529917 |