ミナミ　ユウイチロウ   Yuichiro Minami   南　雄一郎    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Prognostic implications of prealbumin level on admission in patients with acute heart failure referred to a cardiac intensive care unit.
掲載誌名	正式名：Journal of cardiology 略　 称：J Cardiol ISSNコード：0914-5087/1876-4738
掲載区分	国内
出版社	Elsevier B.V.
巻・号・頁	73(2),pp.114-119
著者・共著者	AKASHI Madoka†, MINAMI Yuichiro*, HARUKI Shintaro, JUJO Kentaro, HAGIWARA Nobuhisa
担当区分	責任著者
発行年月	2019/02
概要	BACKGROUND: Prealbumin is a marker of nutritional and inflammatory status, and low prealbumin level at discharge is associated with poor outcome in hospitalized patients with heart failure. However, the prognostic value of prealbumin level on admission in patients with acute heart failure (AHF) has not been established, especially in an acute care setting. We aimed to clarify the association between prealbumin level on admission and outcome in patients with AHF referred to a cardiac intensive care unit. METHODS: We analyzed 186 hospitalized patients with AHF who had their prealbumin level examined within 24h of admission. RESULTS: The mean prealbumin level was 16.6±6.5mg/dL. Prealbumin effectively predicted all-cause death during the median follow-up period of 276 days, using receiver operating characteristic (ROC) curve analysis (the area under the ROC curve; 0.722, optimal cut-off point; ≤14.0mg/dL, sensitivity 71.0%; specificity 69.7%; p<0.001). The all-cause mortality and the composite endpoints of all-cause death or readmission for AHF in patients with low prealbumin level (≤14.0mg/dL) were significantly higher than in patients with high prealbumin level (log-rank p<0.001 and p=0.002). Multivariate analysis adjusted for established markers of AHF severity showed that prealbumin ≤14.0mg/dL was independently associated with higher mortality (hazard ratio 4.79; 95% confidence interval 1.89-12.2; p=0.001) and with the composite endpoints (hazard ratio 2.38; 95% confidence interval 1.30-4.36; p=0.005). CONCLUSIONS: Prealbumin level on admission may be useful in the risk stratification of patients with AHF in an acute care setting.
DOI	10.1016/j.jjcc.2018.08.003
PMID	30366636