マツウラ カツヒサ   MATSUURA Katsuhisa
  松浦 勝久
   所属   研究施設 研究施設
   職種   准教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis.
掲載誌名 正式名:EBioMedicine
略  称:EBioMedicine
ISSNコード:(2352-3964)2352-3964(Linking)
掲載区分国外
巻・号・頁 42,43-53頁
著者・共著者 TAKAHARA Shingo†, INOUE Shin-ichi, MIYAGAWA-TOMITA Sachiko, MATSUURA Katsuhisa, NAKASHIMA Yasumi, NIIHORI Tetsuya, MATSUBARA Yoichi, SAIKI Yoshikatsu, AOKI Yoko*
発行年月 2019/04
概要 The A57G mutation in Rit1 causes cardiac hypertrophy, fibrosis and other NS-associated features. Biochemical analysis indicates that the AKT signaling pathway might be related to downstream signaling in the RIT1 A57G mutant at a developmental stage and under β-adrenergic stimulation in the heart. FUND: The Grants-in-Aid were provided by the Practical Research Project for Rare/Intractable Diseases from the Japan Agency for Medical Research and Development, the Japan Society for the Promotion of Science KAKENHI Grant.
DOI 10.1016/j.ebiom.2019.03.014
PMID 30898653