マツウラ　カツヒサ   MATSUURA Katsuhisa   松浦　勝久    所属   研究施設 研究施設    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis.
掲載誌名	正式名：EBioMedicine 略　 称：EBioMedicine ISSNコード：(2352-3964)2352-3964(Linking)
掲載区分	国外
巻・号・頁	42,pp.43-53
著者・共著者	TAKAHARA Shingo†, INOUE Shin-ichi, MIYAGAWA-TOMITA Sachiko, MATSUURA Katsuhisa, NAKASHIMA Yasumi, NIIHORI Tetsuya, MATSUBARA Yoichi, SAIKI Yoshikatsu, AOKI Yoko*
発行年月	2019/04
概要	The A57G mutation in Rit1 causes cardiac hypertrophy, fibrosis and other NS-associated features. Biochemical analysis indicates that the AKT signaling pathway might be related to downstream signaling in the RIT1 A57G mutant at a developmental stage and under β-adrenergic stimulation in the heart. FUND: The Grants-in-Aid were provided by the Practical Research Project for Rare/Intractable Diseases from the Japan Agency for Medical Research and Development, the Japan Society for the Promotion of Science KAKENHI Grant.
DOI	10.1016/j.ebiom.2019.03.014
PMID	30898653