増井　憲太    Department   School of Medicine, School of Medicine    Position   Associate Professor
Article types	Case report
Language	English
Peer review	Non peer reviewed
Title	A case of lymphangioleiomyomatosis with diffuse large B-cell lymphoma: Usefulness of FDG-PET.
Journal	Formal name：Respiratory medicine case reports Abbreviation：Respir Med Case Rep ISSN code：22130071/22130071
Domestic / Foregin	Foregin
Volume, Issue, Page	29,pp.100999
Author and coauthor	ORIMO Mami†, KONDO Mitsuko, TAKEYAMA Kiyoshi, MASUI Kenta, TANAKA Junji, TAGAYA Etsuko
Publication date	2020
Summary	Lymphangioleiomyomatosis (LAM) is characterized by cystic lung disease, abdominal tumor and involvement of the axial lymph nodes. We report a very rare case of LAM with malignant lymphoma. A 51-year-old female had medical history of recurrent pneumothorax and nephrectomy for a left renal angiomyolipoma and was diagnosed with LAM by video-assisted thoracoscopic surgery at the age of 30. She presented with left neck mass. Computed tomography and magnetic response imaging showed multiple enlarged cervical lymph nodes. 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) showed abnormal uptake in the mass. We suspected a malignant tumor or extrapulmonary lesion of LAM, and performed surgical biopsy. Pathologically, diffuse large B-cell lymphoma was diagnosed, but LAM was not detected. After she received six cycles of R-CHOP chemotherapy, FDG-PET turned negative and complete metabolic response was achieved. As LAM is reported to be silent for FDG-PET, unusual uptake of FDG is useful for identifying other neoplasms. For this case, FDG-PET was useful for the differential diagnosis and therapeutic evaluation.
DOI	10.1016/j.rmcr.2020.100999
PMID	32257785