Kuribayashi Shigehiko    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Assistant Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Post-keloidectomy irradiation using high-dose-rate superficial brachytherapy
Journal	Formal name：Journal of radiation research Abbreviation：J Radiat Res (Tokyo) ISSN code：04493060/13499157
Domestic / Foregin	Domestic
Volume, Issue, Page	52(3),pp.365-368
Author and coauthor	KURIBAYASHI Shigehiko, MIYASHITA Tsuguhiro, OZAWA Yukiko, IWANO Marie, OGAWA Rei, AKAISHI Satoshi, DOHI Teruyuki, HYAKUSOKU Hiko, KUMITA Shinichiro.
Authorship	Lead author
Publication date	2011/04/14
Summary	A study was conducted to evaluate the early results of high-dose-rate superficial brachytherapy (HDR-SB) after keloidectomy. Between April 2008 and April 2009, 21 patients with 36 histologically confirmed keloids were treated with postoperative HDR-SB. The tube applicator was placed on the skin to match the area of the surgical wound, and a spacer 5 mm thick was placed between the skin and the applicator. A dose evaluation point was established below 2 mm from skin surface, and 20 Gy was delivered in 4 daily fractions to keloidectomy scars on the anterior chest wall, scapular region, lower jaw and suprapubic region. A dose of 15 Gy was delivered in 3 daily fractions to lesions in other areas. The median follow-up period was 18 months (range, 9 to 29 months). Therapeutic outcome was judged in terms of recurrence, control, or acute side effects. Three keloids (9.7%) in two patients showed local recurrence, with a median time to failure after HDR-SB of 12 months. All recurrences affected the anterior chest wall. Dysraphia occurred in only one patient with an anterior chest wall lesion. Excluding the cases of recurrence, acceptable cosmetic results were achieved. Our results indicate that HDR-SB is effective and safe for preventing recurrence of keloids.
DOI	10.1269/jrr.10159