クリバヤシ　シゲヒコ   Kuribayashi Shigehiko   栗林　茂彦    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Post-keloidectomy irradiation using high-dose-rate superficial brachytherapy
掲載誌名	正式名：Journal of radiation research 略　 称：J Radiat Res (Tokyo) ISSNコード：04493060/13499157
掲載区分	国内
巻・号・頁	52(3),pp.365-368
著者・共著者	KURIBAYASHI Shigehiko, MIYASHITA Tsuguhiro, OZAWA Yukiko, IWANO Marie, OGAWA Rei, AKAISHI Satoshi, DOHI Teruyuki, HYAKUSOKU Hiko, KUMITA Shinichiro.
担当区分	筆頭著者
発行年月	2011/04/14
概要	A study was conducted to evaluate the early results of high-dose-rate superficial brachytherapy (HDR-SB) after keloidectomy. Between April 2008 and April 2009, 21 patients with 36 histologically confirmed keloids were treated with postoperative HDR-SB. The tube applicator was placed on the skin to match the area of the surgical wound, and a spacer 5 mm thick was placed between the skin and the applicator. A dose evaluation point was established below 2 mm from skin surface, and 20 Gy was delivered in 4 daily fractions to keloidectomy scars on the anterior chest wall, scapular region, lower jaw and suprapubic region. A dose of 15 Gy was delivered in 3 daily fractions to lesions in other areas. The median follow-up period was 18 months (range, 9 to 29 months). Therapeutic outcome was judged in terms of recurrence, control, or acute side effects. Three keloids (9.7%) in two patients showed local recurrence, with a median time to failure after HDR-SB of 12 months. All recurrences affected the anterior chest wall. Dysraphia occurred in only one patient with an anterior chest wall lesion. Excluding the cases of recurrence, acceptable cosmetic results were achieved. Our results indicate that HDR-SB is effective and safe for preventing recurrence of keloids.
DOI	10.1269/jrr.10159