Kuribayashi Shigehiko
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Utility of sonography for evaluation of clinical T1 and T2 glottic carcinoma.
Journal Formal name：Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
Abbreviation：J Ultrasound Med
ISSN code：15509613/02784297
Domestic / ForeginForegin
Volume, Issue, Page 28(11),pp.1429-1440
Author and coauthor KURIBAHASHI Shigehiko, MIYASHITA Tsuguhiro, NAKAMIZO Munenaga, YAGI Toshiaki, KUMITA Shinichiro
Authorship Lead author
Publication date 2009/11
Summary OBJECTIVE:The aim of this study was to evaluate the prognostic impact of sonographically determined tumor features in relation to local control of clinical T1 and T2 glottic carcinoma treated by definitive radiation therapy.METHODS:Between 1999 and 2005, 72 patients with T1 and T2 glottic carcinoma were evaluated by percutaneous sonography in terms of tumor detectability, maximum tumor dimension, involvement of the anterior commissure, presence of supraglottic, subglottic, or paraglottic spread, and thyroid cartilage invasion. Factor analyses for local control included clinical features, sonographic findings, and treatment factors.RESULTS:Forty-one lesions (57%) were detected as hypoechoic masses on sonography. For detectable T2 tumors, sonographic and laryngoscopic findings were in agreement in all cases with respect to spread to anatomic subsites. The 3-year local control rate with radiation therapy alone was 82%. Univariate analysis of the sonographic characteristics revealed that the maximum tumor dimension and thyroid cartilage invasion predicted a loss of local control, whereas none of the clinical or treatment characteristics was significant. Multivariate analysis showed that thyroid cartilage invasion was an independent negative prognostic factor for local control.CONCLUSIONS:Sonography provides information about the likely outcome of radiation therapy for patients with clinical T2 glottic carcinoma, although its utility for T1 lesions is not proven. Thyroid cartilage invasion may be an independent negative predictor of the outcome.
DOI 10.7863/jum.2009.28.11.1429
PMID 19854956