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WATANABE Daisuke
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Evaluation of insulin sensitivity and secretion in primary aldosteronism. |
| Journal | Formal name：Clinical and experimental hypertension (New York, N.Y. : 1993) Abbreviation：Clin Exp Hypertens ISSN code：15256006/10641963 |
| Domestic / Foregin | Domestic |
| Volume, Issue, Page | 38(7),pp.613-617 |
| Author and coauthor | Watanabe Daisuke, Yatabe Midori, Ichihara Atsuhiro |
| Authorship | Lead author |
| Publication date | 2016/09 |
| Summary | In primary aldosteronism (PA), insulin response to glucose is not fully understood. Insulin action was elucidated using indices in 32 PA and 21 essential hypertension (EH) patients. These patients were evaluated using homeostasis model assessment (HOMA) indices, quantitative insulin sensitivity check index (QUICKI), and insulinogenic index (IGI), which were expressed for insulin sensitivity/secretion and the early phase of insulin secretion. Insulin sensitivity and early phase of insulin secretion were decreased in PA, and there was a negative correlation between serum potassium concentration and insulin sensitivity indices. These findings suggest that glucose intolerance in PA may be caused by hypokalemia-induced insulin resistance and hypokalemia-independent impairment of early-phase insulin secretion. |
| DOI | 10.1080/10641963.2016.1182176 |
| PMID | 27669369 |