ワタナベ　ダイスケ   WATANABE Daisuke   渡辺　大輔    所属   医学部 医学科（東京女子医科大学病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Evaluation of insulin sensitivity and secretion in primary aldosteronism.
掲載誌名	正式名：Clinical and experimental hypertension (New York, N.Y. : 1993) 略　 称：Clin Exp Hypertens ISSNコード：15256006/10641963
掲載区分	国内
巻・号・頁	38(7),pp.613-617
著者・共著者	Watanabe Daisuke, Yatabe Midori, Ichihara Atsuhiro
担当区分	筆頭著者
発行年月	2016/09
概要	In primary aldosteronism (PA), insulin response to glucose is not fully understood. Insulin action was elucidated using indices in 32 PA and 21 essential hypertension (EH) patients. These patients were evaluated using homeostasis model assessment (HOMA) indices, quantitative insulin sensitivity check index (QUICKI), and insulinogenic index (IGI), which were expressed for insulin sensitivity/secretion and the early phase of insulin secretion. Insulin sensitivity and early phase of insulin secretion were decreased in PA, and there was a negative correlation between serum potassium concentration and insulin sensitivity indices. These findings suggest that glucose intolerance in PA may be caused by hypokalemia-induced insulin resistance and hypokalemia-independent impairment of early-phase insulin secretion.
DOI	10.1080/10641963.2016.1182176
PMID	27669369