ワタナベ ダイスケ
WATANABE Daisuke
渡辺 大輔 所属 医学部 医学科(東京女子医科大学病院) 職種 講師 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Prediction of gestational diabetes mellitus by soluble (pro)renin receptor during the first trimester. |
掲載誌名 | 正式名:The Journal of clinical endocrinology and metabolism 略 称:J Clin Endocrinol Metab ISSNコード:1945-7197(Electronic)0021-972X(Linking) |
巻・号・頁 | 98(6),pp.2528-35 |
著者・共著者 | WATANABE Noriyoshi†, MORIMOTO Satoshi, FUJIWARA Takeo, SUZUKI Tomo, TANIGUCHI Kosuke, MORI Fumiko, ANDO Takashi, WATANABE Daisuke, KIMURA Tadashi, SAGO Haruhiko, ICHIHARA Atsuhiro* |
発行年月 | 2013/06 |
概要 | CONTEXT:There are currently no factors that have been shown to predict gestational diabetes mellitus (GDM) during early pregnancy. The soluble (pro)renin receptor [s(P)RRCONTEXT:]CONTEXT:may contribute to the development of GDM.OBJECTIVE:The objective of the study was to determine whether plasma s(P)RR concentrations during early pregnancy are associated with the development of GDM later in pregnancy.DESIGN, SETTING, AND PARTICIPANTS:This prospective cohort study was conducted at a referral birth center. Pregnant women who first visited our hospital during the first trimester (DESIGN, SETTING, AND PARTICIPANTS:<DESIGN, SETTING, AND PARTICIPANTS:14 weeks of gestation) between 2010 and 2011 were enrolled. Inclusion criteria included singleton pregnancy and the absence of preexisting diabetes mellitus. A total of 716 women participated in this study.MAIN OUTCOME MEASURE:The association of plasma s(P)RR concentrationsMAIN OUTCOME MEASURE:with the onset of GDM later in pregnancy was measured.RESULTS:Among 716 participants, 44 (6.1%) had GDM and 672 (93.9%) did not. There were 176 participants in the first plasma s(P)RR concentration quartile (Q1:RESULTS:<RESULTS:25.8 ng/mL), 179 in the second (Q2: 25.8-30.2 ng/mL), 181 in the third (Q3: 30.2-34.2 ng/mL), and 180 in the fourth (Q4:RESULTS:>RESULTS:34.2 ng/mL). GDM distribution was 7 (4.0%) in Q1, 5 (2.8%) in Q2, 13 (7.2%) in Q3, and 19 (10.6%) in Q4. A multivariate model adjusted for baseline characteristics, medical complications, and gestational characteristics revealed that the risk of developing GDM among women in Q4 compared with Q1 was 2.90 (95% confidence interval 1.11-7.49).CONCLUSION:Increased s(P)RR concentrations during the first trimester may predict the development of GDM later in pregnancy. |
DOI | 10.1210/jc.2012-4139 |
文献番号 | 23720787 |