タキタ　モリチカ   Morichika Takita   瀧田　守親    所属   医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Prostaglandin E receptor EP4 antagonist suppresses osteolysis due to bone metastasis of mouse malignant melanoma cells.
掲載誌名	正式名：FEBS Letters 略　 称：FEBS Lett. ISSNコード：18733468
掲載区分	国外
巻・号・頁	581(3),pp.565-571
著者・共著者	Takita Morichika†, Inada Masaki, Maruyama Takayuki, Miyaura Chisato*
担当区分	筆頭著者
発行年月	2007/01
概要	We examined the effects of prostaglandin E (PGE) receptor subtype EP4 antagonist on bone metastasis of cancer to clarify PGE's role in bone metastasis. Metastatic regions were detected in femurs accompanying severe bone loss in mice injected with B16 malignant melanoma cells. Administration of EP4 antagonist restored the bone loss induced by B16 melanoma. Adding B16 cells induced osteoclast formation in the coculture of bone marrow cells and osteoblasts without any exogenous bone-resorbing factor, and EP4 antagonist completely suppressed the osteoclast formation induced by B16 cells. Therefore, EP4 antagonist is a possible candidate for the therapy of bone metastasis of cancer.
DOI	10.1016/j.febslet.2007.01.005
researchmap用URL	http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1016/j.febslet.2007.01.005