Morichika Takita
   Department   School of Medicine, School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Nobiletin, a polymethoxy flavonoid, suppresses bone resorption by inhibiting NFκB-dependent prostaglandin E synthesis in osteoblasts and prevents bone loss due to estrogen deficiency.
Journal Formal name:Journal of Pharmacological Sciences
Abbreviation:J. Pharmacol. Sci.
ISSN code:13478613/13478648
Domestic / ForeginDomestic
Publisher The Japanese Pharmacological Society
Volume, Issue, Page 115,pp.89-93
Author and coauthor Harada Suguru†, Tominari Tsukasa, Matsumoto Chiho, Hirata Michiko, Takita Morichika, Inada Masaki, Miyaura Chisato*
Publication date 2011/01
Summary Nobiletin, a polymethoxy flavonoid, prevents cancer and inflammation, but the roles of nobiletin in bone are unclear. We examined the effects of nobiletin on bone resorption in vitro and on bone mass in ovariectomized (OVX) mice in vivo. In vitro, nobiletin suppressed osteoclast formation and bone resorption induced by interleukin (IL)-1. Nobiletin suppressed the expression of cyclooxygenase-2, NFκB-dependent transcription, and prostaglandin E (PGE) production induced by IL-1 in osteoblasts. OVX mice showed severe bone loss in the femur by increased bone resorption due to estrogen deficiency, and nobiletin significantly restored the bone mass. Nobiletin could be beneficial to bone health in postmenopausal women.
DOI 10.1254/jphs.10193SC
PMID 21258168