タキタ モリチカ   TAKITA Morichika
  瀧田 守親
   所属   医学部 医学科
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Nobiletin, a polymethoxy flavonoid, suppresses bone resorption by inhibiting NFκB-dependent prostaglandin E synthesis in osteoblasts and prevents bone loss due to estrogen deficiency.
掲載誌名 正式名:Journal of Pharmacological Sciences
略  称:J. Pharmacol. Sci.
ISSNコード:13478613/13478648
掲載区分国内
出版社 The Japanese Pharmacological Society
巻・号・頁 115,pp.89-93
著者・共著者 Harada Suguru†, Tominari Tsukasa, Matsumoto Chiho, Hirata Michiko, Takita Morichika, Inada Masaki, Miyaura Chisato*
発行年月 2011/01
概要 Nobiletin, a polymethoxy flavonoid, prevents cancer and inflammation, but the roles of nobiletin in bone are unclear. We examined the effects of nobiletin on bone resorption in vitro and on bone mass in ovariectomized (OVX) mice in vivo. In vitro, nobiletin suppressed osteoclast formation and bone resorption induced by interleukin (IL)-1. Nobiletin suppressed the expression of cyclooxygenase-2, NFκB-dependent transcription, and prostaglandin E (PGE) production induced by IL-1 in osteoblasts. OVX mice showed severe bone loss in the femur by increased bone resorption due to estrogen deficiency, and nobiletin significantly restored the bone mass. Nobiletin could be beneficial to bone health in postmenopausal women.
DOI 10.1254/jphs.10193SC
PMID 21258168