Morichika Takita
   Department   School of Medicine, School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Capsaicin, a ligand for vanilloid receptor-1, transduces suppressive signal for osteoclast differentiation in bone.
Journal Formal name:Journal of Health Science
Abbreviation:J. Health Sci.
ISSN code:13449702/13475207
Domestic / ForeginDomestic
Publisher Pharmaceutical Society of JAPAN
Volume, Issue, Page 53(2),pp.240-244
Author and coauthor Takita Morichika†, Inada Masaki, Miyaura Chisato*
Authorship Lead author
Publication date 2007/04
Summary Vanilloid receptor-1 (VR1) has been reported to exhibit multiple functions which can transduce pain-sensitive signals in nerve systems. A VR1 ligand, capsaicin has been reported to show activities against inflammation and cancer growth, however, its role in bone metabolism is still unknown. Here we examined the effect of capsaicin on cytokine-induced inflammatory bone resorption. Capsaicin suppressed interleukin-1-induced bone resorption in mouse calvarial organ ex vivo culture in a dose-dependent manner. An assay using cocultures of osteoblast and bone marrow cells clearly showed the inhibition of osteoclast formation by treatment with capsaicin. Receptor activator of NF-kB ligandRANKL (RANKL), the sole inducer of osteoclast formation, is known to be produced by osteoblasts. In the cocultures of bone marrow cells and osteoblasts, the expression of RANKL was suppressed by capsaicin. VR1 showed expression predominantly in osteoblast, suggesting that capsaicin directly modulates osteoclast differentiation through the suppression of RANKL expression. VR1 ligands like capsaicin have the potential for use as clinical drugs targeting some bone diseases involving cytokine-induced bone resorption.