植田 禎史
   Department   School of Medicine, School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Layer-specific sensory processing impairment in the primary somatosensory cortex after motor cortex infarction
Journal Formal name:Scientific Reports
Abbreviation:Sci Rep
ISSN code:20452322
Domestic / ForeginForegin
Publisher Springer Nature
Volume, Issue, Page 10(1),3771頁
Author and coauthor FUKUI Atsushi†, OSAKI Hironobu†*, UETA Yoshifumi, KOBAYASHI kenta, MURAGAKI Yoshihiro, KAWAMATA Takakazu, MIYATA Mariko*
Publication date 2020/02/28
Summary Primary motor cortex (M1) infarctions sometimes cause sensory impairment. Because sensory signals play a vital role in motor control, sensory impairment compromises the recovery and rehabilitation of motor disability. However, the neural mechanism of the sensory impairment is poorly understood. We show that sensory processing in mouse primary somatosensory cortex (S1) was impaired in the acute phase of M1 infarctions and recovered in a layer-specific manner in the subacute phase. This layer-dependent recovery process and the anatomical connection pattern from M1 to S1 suggested that functional connectivity from M1 to S1 plays a key role in the sensory processing impairment. A simulation study demonstrated that the loss of inhibition from M1 to S1 in the acute phase of M1 infarctions could impair sensory processing in S1, and compensation for the inhibition could recover the temporal coding. Consistently, the optogenetic activation of M1 suppressed the sustained response in S1. Taken together, we revealed how focal stroke in M1 alters the cortical network activity of sensory processing, in which inhibitory input from M1 to S1 may be involved.
DOI 10.1038/s41598-020-60662-7
PMID 32111927