ウエタ ヨシフミ
  植田 禎史
   所属   医学部 医学科
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Multiple layer 5 pyramidal cell subtypes relay cortical feedback from secondary to primary motor areas in rats.
掲載誌名 正式名:Cerebral Cortex
略  称:Cereb Cortex
ISSNコード:10473211/14602199
巻・号・頁 24(9),2362-2376頁
著者・共著者 Ueta Yoshifumi†, Otsuka Takeshi, Morishima Mieko, Ushimaru Mika, Kawaguchi Yasuo*
発行年月 2014/09
概要 Higher-order motor cortices, such as the secondary motor area (M2) in rodents, select future action patterns and transmit them to the primary motor cortex (M1). To better understand motor processing, we characterized"top-down"and"bottom-up"connectivities between M1 and M2 in the rat cortex. Somata of pyramidal cells (PCs) in M2 projecting to M1 were distributed in lower layer 2/3 (L2/3) and upper layer 5 (L5), whereas PCs projecting from M1 to M2 had somata distributed throughout L2/3 and L5. M2 afferents terminated preferentially in upper layer 1 of M1, which also receives indirect basal ganglia output through afferents from the ventral anterior and ventromedial thalamic nuclei. On the other hand, M1 afferents terminated preferentially in L2/3 of M2, a zone receiving indirect cerebellar output through thalamic afferents from the ventrolateral nucleus. While L5 corticopontine (CPn) cells with collaterals to the spinal cord did not participate in corticocortical projections, CPn cells with collaterals to the thalamus contributed preferentially to connections from M2 to M1. L5 callosal projection (commissural) cells participated in connectivity between M1 and M2 bidirectionally. We conclude that the connectivity between M1 and M2 is directionally specialized, involving specific PC subtypes that selectively target lamina receiving distinct thalamocortical inputs.
DOI cercor/bht088
文献番号 23551921
PMID 23551921