ウエタ ヨシフミ
  植田 禎史
   所属   医学部 医学科
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Selective Thalamic Innervation of Rat Frontal Cortical Neurons.
掲載誌名 正式名:Cerebral Cortex
略  称:Cereb Cortex
ISSNコード:10473211/14602199
掲載区分国外
巻・号・頁 26(6),2689-2704頁
著者・共著者 Shigematsu Naoki†, Ueta Yoshifumi, Mohamed A. Alsayed, Hatada Sayuri, Fukuda Takaichi, Kubota Yoshiyuki, Kawaguchi Yasuo*
発行年月 2016/06
概要 UNASSIGNED:Most glutamatergic inputs in the neocortex originate from the thalamus or neocortical pyramidal cells. To test whether thalamocortical afferents selectively innervate specific cortical cell subtypes and surface domains, we investigated the distribution patterns of thalamocortical and corticocortical excitatory synaptic inputs in identified postsynaptic cortical cell subtypes using intracellular and immunohistochemical staining combined with confocal laser scanning and electron microscopic observations in 2 thalamorecipient sublayers, lower layer 2/3 (L2/3b) and lower layer 5 (L5b) of rat frontal cortex. The dendrites of GABAUNASSIGNED:ergic parvalbumin (PV) cells preferentially received corticocortical inputs in both sublayers. The somata of L2/3b PV cells received thalamic inputs in similar proportions to the basal dendritic spines of L2/3b pyramidal cells, whereas L5b PV somata were mostly innervated by cortical inputs. The basal dendrites of L2/3b pyramidal and L5b corticopontine pyramidal cells received cortical and thalamic glutamatergic inputs in proportion to their local abundance, whereas crossed-corticostriatal pyramidal cells in L5b exhibited a preference for thalamic inputs, particularly in their distal dendrites. Our data demonstrate an exquisite selectivity among thalamocortical afferents in which synaptic connectivity is dependent on the postsynaptic neuron subtype, cortical sublayer, and cell surface domain.
DOI 10.1093/cercor/bhv124
文献番号 26045568
PMID 26045568