ヨシナ サワコ   Yoshina Sawako
  吉名 佐和子
   所属   医学部 医学科
   職種   講師
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Cysteine protease cathepsin B mediates radiation-induced bystander effects.
掲載誌名 正式名:Nature
略  称:Nature
ISSNコード:(1476-4687)0028-0836(Linking)
掲載区分国外
巻・号・頁 547(7664),458-462頁
著者・共著者 Peng Yu, Zhang Man, Zheng Lingjun, Liang Qian, Li Hanzeng, Chen Jeng-Ting, Guo Hongyan, Yoshina Sawako, Chen Yu-Zen, Zhao Xiang, Wu Xiaoqi, Liu Bin, Mitani Shohei, Yu Jau-Song, Xue Ding
発行年月 2017/07
概要 The radiation-induced bystander effect (RIBE) refers to a unique process in which factors released by irradiated cells or tissues exert effects on other parts of the animal not exposed to radiation, causing genomic instability, stress responses and altered apoptosis or cell proliferation. Although RIBEs have important implications for radioprotection, radiation safety and radiotherapy, the molecular identities of RIBE factors and their mechanisms of action remain poorly understood. Here we use Caenorhabditis elegans as a model in which to study RIBEs, and identify the cysteine protease CPR-4, a homologue of human cathepsin B, as the first RIBE factor in nematodes, to our knowledge. CPR-4 is secreted from animals irradiated with ultraviolet or ionizing gamma rays, and is the major factor in the conditioned medium that leads to the inhibition of cell death and increased embryonic lethality in unirradiated animals. Moreover, CPR-4 causes these effects and stress responses at unexposed sites distal to the irradiated tissue. The activity of CPR-4 is regulated by the p53 homologue CEP-1 in response to radiation, and CPR-4 seems to exert RIBEs by acting through the insulin-like growth factor receptor DAF-2. Our study provides crucial insights into RIBEs, and will facilitate the identification of additional RIBE factors and their mechanisms of action.
DOI 10.1038/nature23284
PMID 28723894