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KODAMA Takashi
Department School of Medicine, School of Medicine Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | The transcription factor Tbx5 regulates direction-selective retinal ganglion cell development and image stabilization. |
| Journal | Formal name：Current biology : CB Abbreviation：Curr Biol ISSN code：18790445/09609822 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 32(19),pp.4286-4298.e5 |
| Author and coauthor | Al-Khindi Timour, Sherman Michael B, Kodama Takashi, Gopal Preethi, Pan Zhiwei, Kiraly James K, Zhang Hao, Goff Loyal A, du Lac Sascha, Kolodkin Alex L |
| Publication date | 2022/10 |
| Summary | The diversity of visual input processed by the mammalian visual system requires the generation of many distinct retinal ganglion cell (RGC) types, each tuned to a particular feature. The molecular code needed to generate this cell-type diversity is poorly understood. Here, we focus on the molecules needed to specify one type of retinal cell: the upward-preferring ON direction-selective ganglion cell (up-oDSGC) of the mouse visual system. Single-cell transcriptomic profiling of up- and down-oDSGCs shows that the transcription factor Tbx5 is selectively expressed in up-oDSGCs. The loss of Tbx5 in up-oDSGCs results in a selective defect in the formation of up-oDSGCs and a corresponding inability to detect vertical motion. A downstream effector of Tbx5, Sfrp1, is also critical for vertical motion detection but not up-oDSGC formation. These results advance our understanding of the molecular mechanisms that specify a rare retinal cell type and show how disrupting this specification leads to a corresponding defect in neural circuitry and behavior. |
| DOI | 10.1016/j.cub.2022.07.064 |
| PMID | 35998637 |