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KODAMA Takashi
Department School of Medicine, School of Medicine Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis. |
| Journal | Formal name：eLife Abbreviation：Elife ISSN code：2050084X/2050084X |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 9,pp.58613 |
| Author and coauthor | Fujita Hirofumi, Kodama Takashi, du Lac Sascha |
| Authorship | 2nd author |
| Publication date | 2020/07 |
| Summary | The cerebellar vermis, long associated with axial motor control, has been implicated in a surprising range of neuropsychiatric disorders and cognitive and affective functions. Remarkably little is known, however, about the specific cell types and neural circuits responsible for these diverse functions. Here, using single-cell gene expression profiling and anatomical circuit analyses of vermis output neurons in the mouse fastigial (medial cerebellar) nucleus, we identify five major classes of glutamatergic projection neurons distinguished by gene expression, morphology, distribution, and input-output connectivity. Each fastigial cell type is connected with a specific set of Purkinje cells and inferior olive neurons and in turn innervates a distinct collection of downstream targets. Transsynaptic tracing indicates extensive disynaptic links with cognitive, affective, and motor forebrain circuits. These results indicate that diverse cerebellar vermis functions could be mediated by modular synaptic connections of distinct fastigial cell types with posturomotor, oromotor, positional-autonomic, orienting, and vigilance circuits. |
| DOI | 10.7554/eLife.58613 |
| PMID | 32639229 |