ヤギシタ ダイゴ   YAGISHITA Daigo
  柳下 大悟
   所属   医学部 医学科(東京女子医科大学病院)
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Time interval from left ventricular stimulation to QRS onset is a novel predictor of nonresponse to cardiac resynchronization therapy.
掲載誌名 正式名:Heart rhythm
略  称:Heart Rhythm
ISSNコード:1547-5271/1556-3871
掲載区分国外
出版社 Elsevier B.V.
巻・号・頁 16(3),395-402頁
著者・共著者 YAGISHITA Daigo†, SHODA Morio*, YAGISHITA Yoshimi, EJIMA Koichiro, HAGIWARA Nobuhisa
発行年月 2019/03
概要 BACKGROUND:
Left ventricular (LV) lead placement at the late activation site (LAS) has been proposed as an optimal LV pacing site (ie, Q-LV interval). However, LAS may be relevant to local electrical conduction, measured as an interval from LV pacing stimulation to QRS onset (S-QRS interval).

OBJECTIVE:
The purpose of this study was to evaluate the prognostic value of S-QRS for reverse remodeling and the impact of S-QRS on pacing QRS configuration in patients undergoing cardiac resynchronization therapy (CRT).

METHODS:
Sixty consecutive heart failure patients with a wide QRS complex underwent CRT. A site with Q-LV ≥95 ms was targeted for LV lead placement. A responder was defined as one with >15% reduction in LV end-systolic volume 6 months after CRT.

RESULTS:
LV lead placement with Q-LV ≥95 ms was achieved in 52 of 60 patients (86.7%). Thirty-two of 52 patients (61.5%) were responders. S-QRS was significantly shorter in responders than nonresponders (P <.01), whereas Q-LV was not significantly different. A cutoff value of 37 ms for S-QRS had sensitivity and specificity of 81% and 90%, respectively. Shorter S-QRS (<37 ms) showed significantly narrower LV pacing QRS width and biventricular pacing QRS width compared to longer S-QRS. After multivariate analysis, PQ interval (odds ratio 0.97; P = .01) and long S-QRS ≥ 37ms (odds ratio 0.014; P <.01) were independent predictors of response to CRT.

CONCLUSION:
In addition to a sufficient Q-LV, S-QRS can be a useful indicator of optimal LV lead position to achieve reverse remodeling. S-QRS contributes to the pacing QRS configuration associated with CRT response.
DOI 10.1016/j.hrthm.2018.08.035
PMID 30193853