ISAMU Miura    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Assistant Professor
Article types	Review article
Language	English
Peer review	Peer reviewed
Presence of invitation	Invited paper
Title	Imaging the Neural Circuit Basis of Social Behavior: Insights from Mouse and Human Studies.
Journal	Formal name：Neurologia medico-chirurgica Abbreviation：Neurol Med Chir (Tokyo) ISSN code：13498029/04708105
Domestic / Foregin	Domestic
Volume, Issue, Page	60(9),pp.429-438
Author and coauthor	Miura Isamu, Overton Eric T N, Nakai Nobuhiro, Kawamata Takakazu, Sato Masaaki, Takumi Toru
Publication date	2020/09
Summary	Social behavior includes a variety of behaviors that are expressed between two or more individuals. In humans, impairment of social function (i.e., social behavior and social cognition) is seen in neurodevelopmental and neurological disorders including autism spectrum disorders (ASDs) and stroke, respectively. In basic neuroscience research, fluorescence monitoring of neural activity, such as immediate early gene (IEG)-mediated whole-brain mapping, fiber photometry, and calcium imaging using a miniaturized head-mounted microscope or a two-photon microscope, and non-fluorescence imaging such as functional magnetic resonance imaging (fMRI) are increasingly used to measure the activity of many neurons and multiple brain areas in animals during social behavior. In this review, we overview recent rodent studies that have investigated the dynamics of brain activity during social behavior at the whole-brain and local circuit levels and studies that explored the neural basis of social function in healthy, in brain-injured, and in autistic human subjects. A synthesis of such findings will advance our understanding of brain mechanisms underlying social behavior and facilitate the development of pharmaceutical and functional neurosurgical interventions for brain disorders affecting social function.
DOI	10.2176/nmc.ra.2020-0088
PMID	32863321