ミウラ　イサム   ISAMU Miura   三浦　勇    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Encoding of social exploration by neural ensembles in the insular cortex.
掲載誌名	正式名：PLoS biology 略　 称：PLoS Biol ISSNコード：15457885/15449173
掲載区分	国外
巻・号・頁	18(9),pp.e3000584
著者・共著者	Miura Isamu, Sato Masaaki, Overton Eric T N, Kunori Nobuo, Nakai Junichi, Kawamata Takakazu, Nakai Nobuhiro, Takumi Toru
発行年月	2020/09
概要	The insular cortex (IC) participates in diverse complex brain functions, including social function, yet their cellular bases remain to be fully understood. Using microendoscopic calcium imaging of the agranular insular cortex (AI) in mice interacting with freely moving and restrained social targets, we identified 2 subsets of AI neurons-a larger fraction of "Social-ON" cells and a smaller fraction of "Social-OFF" cells-that change their activity in opposite directions during social exploration. Social-ON cells included those that represented social investigation independent of location and consisted of multiple subsets, each of which was preferentially active during exploration under a particular behavioral state or with a particular target of physical contact. These results uncover a previously unknown function of AI neurons that may act to monitor the ongoing status of social exploration while an animal interacts with unfamiliar conspecifics.
DOI	10.1371/journal.pbio.3000584
PMID	32956387