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Takagi Ryo
Department Research Institutes and Facilities, Research Institutes and Facilities Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Effect of basic fibroblast growth factor with collagen/gelatin fixture in a rabbit model of nasal septum perforation. |
| Journal | Formal name：Regenerative therapy Abbreviation：Regen Ther ISSN code：23523204/23523204 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 25,pp.387-394 |
| Author and coauthor | TAKIZAWA Yuki†, MORINO Tsunetaro, TAKAGI Ryo, OTORI Nobuyoshi, KOJIMA Hiromi, YAMATO Masayuki* |
| Publication date | 2024/03 |
| Summary | INTRODUCTION:The treatment of nasal septum perforation solely by surgical intervention presents significant challenges. This study evaluated the effect of basic fibroblast growth factor (bFGF) in combination with collagen/gelatin on wound healing of nasal septum perforation in a rabbit animal model.METHODS:A nasal septum perforation rabbit model was created. bFGF was added to a collagen/gelatin fixture and placed adjacent to the perforation, which is a complete defect. The rabbits were divided into three groups: the sham group that underwent the surgical procedure only, bFGF (-) group that received collagen/gelatin fixture without bFGF, and bFGF(+) group that received collagen/gelatin fixture with bFGF. The dimensions of the perforations were measured after 4 weeks, and the septum was subjected to histological examination.RESULTS:All perforations remained open in the sham group (closure rate: 20.4%-83.1%). The closure rates of the bFGF(-) and bFGF(+) groups were 49.4%-68.8% and 72.7%-100%, respectively. No significant difference was noted in the closure rates between the sham and bFGF(-) groups; however, significant differences were observed between the sham and bFGF(+) groups, and the bFGF(-) and bFGF(+) groups (p < 0.05), indicating that bFGF promoted perforation closure.CONCLUSIONS:The study demonstrated that bFGF with collagen/gelatin carrier promoted wound healing in a rabbit model of nasal septum perforation. |
| DOI | 10.1016/j.reth.2024.02.001 |
| PMID | 38425672 |