MARUKO Ruka
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Endowed Assistant Professor |
|
Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | EVALUATION OF SHORT-TERM OUTCOMES OF INTRAVITREAL AFLIBERCEPT INJECTIONS FOR AGE-RELATED MACULAR DEGENERATION USING FOCAL MACULAR ELECTRORETINOGRAPHY. |
Journal | Formal name:Retina (Philadelphia, Pa.) Abbreviation:Retina ISSN code:15392864/0275004X |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 37(3),pp.553-560 |
Author and coauthor | Takayama Kei, Kaneko Hiroki, Ueno Shinji, Maruko Ruka, Piao Chang-Hua, Yasuda Shunsuke, Kawano Kenichi, Ito Yasuki, Terasaki Hiroko |
Publication date | 2017/03 |
Summary | PURPOSE:To evaluate the relationship between morphological changes and functional improvements assessed using focal macular electroretinograms after intravitreal aflibercept (IVA) injections in eyes with wet age-related macular degeneration.METHODS:The clinical records of 42 eyes of 42 consecutive patients with naive, wet age-related macular degeneration received 3 monthly IVA were reviewed. The best-corrected visual acuity, central foveal thickness, outer retinal thickness, inner retinal thickness at baseline and 1 month after each IVA, and focal macular electroretinograms at baseline and 1 month after the first and third IVA were compared.RESULTS:Best-corrected visual acuity was improved after the third IVA (P = 0.0091). Central foveal thickness and outer retinal thickness showed decreases after every IVA (P < 0.001, respectively). Inner retinal thickness showed a decrease after the second IVA (P = 0.002), after and third IVA (P = 0.001). On focal macular electroretinograms, a- and b-wave amplitudes showed increases after the third IVA (P = 0.0028, P = 0.0012, respectively). Significant correlations were observed between best-corrected visual acuity and central foveal thickness, a-wave amplitude and outer retinal thickness, and b-wave amplitude and inner retinal thickness changes after the third IVA.CONCLUSION:All parameters significantly recovered after three monthly IVA, with a correlation between functional improvements and morphological changes. |
DOI | 10.1097/IAE.0000000000001225 |
PMID | 27465570 |