MARUKO Ruka    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Endowed Assistant Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	One-Year Outcomes of 1 + pro re nata versus 3 + pro re nata Intravitreal Aflibercept Injection for Neovascular Age-Related Macular Degeneration.
Journal	Formal name：Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde Abbreviation：Ophthalmologica ISSN code：14230267/00303755
Domestic / Foregin	Foregin
Volume, Issue, Page	237(2),pp.105-110
Author and coauthor	Takayama Kei, Kaneko Hiroki, Sugita Tadasu, Maruko Ruka, Hattori Kyoko, Ra Eimei, Kawano Kenichi, Kataoka Keiko, Ito Yasuki, Terasaki Hiroko
Publication date	2017
Summary	PURPOSE:We compared 1-year outcomes of 1 + pro re nata (PRN) versus 3 + PRN of intravitreal aflibercept injection (IAI) for age-related macular degeneration (AMD).METHODS:Forty-two eyes with naïve AMD received 3 + PRN IAI treatment and 47 eyes with naïve AMD received 1 + PRN IAI treatment. Visual acuity (VA), central retinal thickness (CRT), and central choroidal thickness (CCT) and number of administered IAIs during 12 months were compared.RESULTS:VAs improved, and CRTs reduced significantly at any given month from baseline in both groups (p < 0.01, respectively). CCT reduced significantly at 3 months in the 3 + PRN group (p = 0.024) but not in the 1 + PRN group. The 1 + PRN group received fewer injections than the 3 + PRN group (p < 0.01).CONCLUSIONS:Aflibercept leads to equivalent VA and morphologic retinal improvement without administering 3 injections.
DOI	10.1159/000461785
PMID	28231566