ミヤヤマ　タカミツ   Takamitsu Miyayama   宮山　貴光    所属   医学部 医学科    職種   助教
論文種別	総説
言語種別	日本語
査読の有無	査読あり
招待の有無	招待あり
表題	Environmental exposure to silver and its health effects
掲載誌名	正式名：Nihon Eiseigaku Zasshi ISSNコード：00215082/00215082
巻・号・頁	67(3),383-9頁
著者・共著者	MIYAYAMA Takamitsu†*, ARAI Yuta, HIRANO Seishiro
担当区分	筆頭著者,責任著者
発行年月	2012/06
概要	Silver (Ag) possesses a well-known antibacterial activity and has been used for medical treatment and cosmetics such as wound dressing and deodorant powders. Occupational Safety and Health Administration (OSHA) and Mine Safety and Health Administration (MSHA) proposed that the permissible exposure limit (PEL) for both metallic and most soluble Ag compounds should be 0.01 mg/m3. Argyria and argyrosis are known to be caused by deposition of insoluble Ag in the dermis and cornea/conjunctiva. However, the metabolic behavior and biological roles of Ag have not been well characterized in mammals. Ag can be absorbed into the systemic circulation from drinking water, and also through parenteral routes such as inhalation and dermal exposure. Experimental studies have demonstrated that Ag+ induces and binds to metallothionein I and II (MTs), which are cysteine-rich proteins, in cells. MTs are major cytoplasmic metal binding proteins and thereby reduce cellular damage caused by toxic heavy metals including Ag. Profiles of Ag distribution in MTs and other Ag-binding proteins can be determined using high performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS). This technique directly provides information on the intracellular behavior of Ag, which is important for elucidating the mechanism underlying Ag toxicity. Silver nanoparticles (AgNPs) are also commercially used mainly as antimicrobial agents. Despite the widespread use of AgNPs, relatively few studies have been undertaken to evaluate the health effects of AgNP exposure. In the present paper, we discuss the absorption, toxicodynamics, and metabolism of both Ag and AgNPs in mammals and their health effects.
DOI	DN/JST.JSTAGE/jjh/67.383 [pii]
文献番号	22781012