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小島 光暁
Department Other, Other Position |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | The role of mesenteric lymph exosomal lipid mediators following intestinal ischemia-reperfusion injury on activation of inflammation. |
| Journal | Formal name：The journal of trauma and acute care surgery Abbreviation：J Trauma Acute Care Surg ISSN code：21630763/21630755 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 89(6),pp.1099 |
| Author and coauthor | Senda Atsushi, Morishita Koji, Kojima Mitsuaki, Doki Sanae, Taylor Beth, Yagi Masayuki, Watanabe Arisa, Kobayashi Tetsuyuki, Aiboshi Junichi, Coimbra Raul, Otomo Yasuhiro |
| Authorship | Lead author |
| Publication date | 2020/07 |
| Summary | BACKGROUND:Intestinal ischemia caused by hemorrhagic shock is known to induce systemic inflammatory responses. Previous studies have shown that mesenteric lymph (ML) plays a crucial role in gut-mediated inflammation. Lipid mediators, such as lysophosphatidylcholines (LPCs) which contain polyunsaturated fatty acids (PUFAs), are present in the post-shock ML. Exosomes are also present in the ML and act as transcellular carriers of lipids; however, their role in post-shock systemic inflammation has not been revealed. Here, we aimed to identify changes in lipid mediators in ML exosomes after intestinal ischemia. |
| DOI | 10.1097/TA.0000000000002897 |
| PMID | 32769950 |