コジマ　ミツアキ   小島　光暁    所属   その他 その他    職種   嘱託医師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	The role of mesenteric lymph exosomal lipid mediators following intestinal ischemia-reperfusion injury on activation of inflammation.
掲載誌名	正式名：The journal of trauma and acute care surgery 略　 称：J Trauma Acute Care Surg ISSNコード：21630763/21630755
掲載区分	国外
巻・号・頁	89(6),pp.1099
著者・共著者	Senda Atsushi, Morishita Koji, Kojima Mitsuaki, Doki Sanae, Taylor Beth, Yagi Masayuki, Watanabe Arisa, Kobayashi Tetsuyuki, Aiboshi Junichi, Coimbra Raul, Otomo Yasuhiro
担当区分	筆頭著者
発行年月	2020/07
概要	BACKGROUND:Intestinal ischemia caused by hemorrhagic shock is known to induce systemic inflammatory responses. Previous studies have shown that mesenteric lymph (ML) plays a crucial role in gut-mediated inflammation. Lipid mediators, such as lysophosphatidylcholines (LPCs) which contain polyunsaturated fatty acids (PUFAs), are present in the post-shock ML. Exosomes are also present in the ML and act as transcellular carriers of lipids; however, their role in post-shock systemic inflammation has not been revealed. Here, we aimed to identify changes in lipid mediators in ML exosomes after intestinal ischemia.
DOI	10.1097/TA.0000000000002897
PMID	32769950