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小島 光暁
Department Other, Other Position |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Gut epithelial cell-derived exosomes trigger posttrauma immune dysfunction. |
| Journal | Formal name：The journal of trauma and acute care surgery Abbreviation：J Trauma Acute Care Surg ISSN code：21630763/21630755 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 84(2),pp.257-264 |
| International coauthorship | International coauthorship |
| Author and coauthor | Kojima Mitsuaki, Costantini Todd W, Eliceiri Brian P, Chan Theresa W, Baird Andrew, Coimbra Raul |
| Authorship | Lead author |
| Publication date | 2018/02 |
| Summary | BACKGROUND:Exosomes are extracellular vesicles that act as endogenous mediators of the immune response. We have previously shown that exosomes released into mesenteric lymph (ML) following trauma (T)/hemorrhagic shock (HS) induce proinflammatory cytokine production in macrophages and are involved in the pathogenesis of postshock acute lung injury. However, the cellular origin of ML exosomes and their role in the posttrauma immune response remains unclear. We hypothesized that exosomes released from damaged-intestinal epithelial cells contribute to posttrauma immune dysfunction by altering the function of dendritic cells (DCs), key regulators of the adaptive immunity. |
| DOI | 10.1097/TA.0000000000001748 |
| PMID | 29194317 |