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コジマ ミツアキ
小島 光暁 所属 その他 その他 職種 嘱託医師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Gut epithelial cell-derived exosomes trigger posttrauma immune dysfunction. |
| 掲載誌名 | 正式名：The journal of trauma and acute care surgery 略 称：J Trauma Acute Care Surg ISSNコード：21630763/21630755 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 84(2),pp.257-264 |
| 国際共著 | 国際共著 |
| 著者・共著者 | Kojima Mitsuaki, Costantini Todd W, Eliceiri Brian P, Chan Theresa W, Baird Andrew, Coimbra Raul |
| 担当区分 | 筆頭著者 |
| 発行年月 | 2018/02 |
| 概要 | BACKGROUND:Exosomes are extracellular vesicles that act as endogenous mediators of the immune response. We have previously shown that exosomes released into mesenteric lymph (ML) following trauma (T)/hemorrhagic shock (HS) induce proinflammatory cytokine production in macrophages and are involved in the pathogenesis of postshock acute lung injury. However, the cellular origin of ML exosomes and their role in the posttrauma immune response remains unclear. We hypothesized that exosomes released from damaged-intestinal epithelial cells contribute to posttrauma immune dysfunction by altering the function of dendritic cells (DCs), key regulators of the adaptive immunity. |
| DOI | 10.1097/TA.0000000000001748 |
| PMID | 29194317 |