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小島 光暁
Department Other, Other Position |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Exosomes in postshock mesenteric lymph are key mediators of acute lung injury triggering the macrophage activation via Toll-like receptor 4. |
| Journal | Formal name：FASEB journal : official publication of the Federation of American Societies for Experimental Biology Abbreviation：FASEB J ISSN code：15306860/08926638 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 32(1),pp.97-110 |
| International coauthorship | International coauthorship |
| Author and coauthor | Kojima Mitsuaki, Gimenes-Junior Joao A, Chan Theresa W, Eliceiri Brian P, Baird Andrew, Costantini Todd W, Coimbra Raul |
| Authorship | Lead author |
| Publication date | 2018/01 |
| Summary | Acute lung injury (ALI) is a common cause of morbidity in patients after severe injury due to dysregulated inflammation, which is believed to be driven by gut-derived inflammatory mediators carried via mesenteric lymph (ML). We have previously demonstrated that nano-sized extracellular vesicles, called exosomes, secreted into ML after trauma/hemorrhagic shock (T/HS) have the potential to activate immune cells in vitro Here, we assess the function of ML exosomes in the development of T/HS-induced ALI and the role of TLR4 in the ML exosome-mediated inflammatory response. |
| DOI | 10.1096/fj.201700488R |
| PMID | 28855278 |