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コジマ ミツアキ
小島 光暁 所属 その他 その他 職種 嘱託医師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Exosomes in postshock mesenteric lymph are key mediators of acute lung injury triggering the macrophage activation via Toll-like receptor 4. |
| 掲載誌名 | 正式名：FASEB journal : official publication of the Federation of American Societies for Experimental Biology 略 称：FASEB J ISSNコード：15306860/08926638 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 32(1),pp.97-110 |
| 国際共著 | 国際共著 |
| 著者・共著者 | Kojima Mitsuaki, Gimenes-Junior Joao A, Chan Theresa W, Eliceiri Brian P, Baird Andrew, Costantini Todd W, Coimbra Raul |
| 担当区分 | 筆頭著者 |
| 発行年月 | 2018/01 |
| 概要 | Acute lung injury (ALI) is a common cause of morbidity in patients after severe injury due to dysregulated inflammation, which is believed to be driven by gut-derived inflammatory mediators carried via mesenteric lymph (ML). We have previously demonstrated that nano-sized extracellular vesicles, called exosomes, secreted into ML after trauma/hemorrhagic shock (T/HS) have the potential to activate immune cells in vitro Here, we assess the function of ML exosomes in the development of T/HS-induced ALI and the role of TLR4 in the ML exosome-mediated inflammatory response. |
| DOI | 10.1096/fj.201700488R |
| PMID | 28855278 |