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コジマ ミツアキ
小島 光暁 所属 その他 その他 職種 嘱託医師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Enteric glia cells are critical to limiting the intestinal inflammatory response after injury. |
| 掲載誌名 | 正式名：American journal of physiology. Gastrointestinal and liver physiology 略 称：Am J Physiol Gastrointest Liver Physiol ISSNコード：15221547/01931857 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 312(3),pp.G274-G282 |
| 著者・共著者 | Langness Simone, Kojima Mitsuaki, Coimbra Raul, Eliceiri Brian P, Costantini Todd W |
| 担当区分 | 2nd著者 |
| 発行年月 | 2017/03 |
| 概要 | Vagal nerve stimulation (VNS) has been shown to limit intestinal inflammation following injury; however, a direct connection between vagal terminals and resident intestinal immune cells has yet to be identified. We have previously shown that enteric glia cell (EGC) expression is increased after injury through a vagal-mediated pathway to help restore gut barrier function. We hypothesize that EGCs modulate immune cell recruitment following injury and relay vagal anti-inflammatory signals to resident immune cells in the gut. |
| DOI | 10.1152/ajpgi.00371.2016 |
| PMID | 28082286 |