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小島 光暁
Department Other, Other Position |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Exosomes, not protein or lipids, in mesenteric lymph activate inflammation: Unlocking the mystery of post-shock multiple organ failure. |
| Journal | Formal name：The journal of trauma and acute care surgery Abbreviation：J Trauma Acute Care Surg ISSN code：21630763/21630755 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 82(1),pp.42-50 |
| Author and coauthor | Kojima Mitsuaki, Gimenes-Junior Joao Antonio, Langness Simone, Morishita Koji, Lavoie-Gagne Ophelie, Eliceiri Brian, Costantini Todd W, Coimbra Raul |
| Authorship | Lead author |
| Publication date | 2017/01 |
| Summary | BACKGROUND:Previous studies have shown that mesenteric lymph (ML) has a crucial role in driving the systemic inflammatory response after trauma/hemorrhagic shock (T/HS). The specific mediators in the ML that contribute to its biological activity remain unclear despite decades of study. Exosomes are extracellular vesicles that are shed into body fluids such as serum and urine that can mediate intercellular communication. We hypothesized that exosomes are present in the ML after trauma/shock and are responsible for the biological activity of ML. |
| DOI | 10.1097/TA.0000000000001296 |
| PMID | 27779585 |