コジマ　ミツアキ   小島　光暁    所属   その他 その他    職種   嘱託医師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Exosomes, not protein or lipids, in mesenteric lymph activate inflammation: Unlocking the mystery of post-shock multiple organ failure.
掲載誌名	正式名：The journal of trauma and acute care surgery 略　 称：J Trauma Acute Care Surg ISSNコード：21630763/21630755
掲載区分	国外
巻・号・頁	82(1),pp.42-50
著者・共著者	Kojima Mitsuaki, Gimenes-Junior Joao Antonio, Langness Simone, Morishita Koji, Lavoie-Gagne Ophelie, Eliceiri Brian, Costantini Todd W, Coimbra Raul
担当区分	筆頭著者
発行年月	2017/01
概要	BACKGROUND:Previous studies have shown that mesenteric lymph (ML) has a crucial role in driving the systemic inflammatory response after trauma/hemorrhagic shock (T/HS). The specific mediators in the ML that contribute to its biological activity remain unclear despite decades of study. Exosomes are extracellular vesicles that are shed into body fluids such as serum and urine that can mediate intercellular communication. We hypothesized that exosomes are present in the ML after trauma/shock and are responsible for the biological activity of ML.
DOI	10.1097/TA.0000000000001296
PMID	27779585