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コジマ ミツアキ
小島 光暁 所属 その他 その他 職種 嘱託医師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Novel role of group VIB Ca2+-independent phospholipase A2γ in leukocyte-endothelial cell interactions: An intravital microscopic study in rat mesentery. |
| 掲載誌名 | 正式名：The journal of trauma and acute care surgery 略 称：J Trauma Acute Care Surg ISSNコード：21630763/21630755 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 79(5),pp.782-9 |
| 著者・共著者 | Kojima Mitsuaki, Aiboshi Junichi, Shibata Masahiro, Kobayashi Tetsuyuki, Otomo Yasuhiro |
| 担当区分 | 筆頭著者 |
| 発行年月 | 2015/11 |
| 概要 | BACKGROUND:Phospholipase A2 (PLA2) is associated with a variety of inflammatory processes related to polymorphonuclear neutrophil (PMN)-endothelial cell interactions. However, the cellular and molecular mechanisms underlying the interactions and the causative isoform(s) of PLA2 remain elusive. In addition, we recently showed that calcium-independent PLA2γ (iPLA2γ), but not cytosolic PLA2 (cPLA2), is responsible for the cytotoxic functions of human PMN including respiratory bursts, degranulation, and chemotaxis. We therefore hypothesized that iPLA2γ is a prerequisite for the PMN recruitment cascade into the site of inflammation. The aim of this study was to elucidate the roles of the three major phospholipases A2, iPLA2, cPLA2 and secretory PLA2, in leukocyte rolling and adherence and in the surface expression of β2-integrins in vivo and in vitro in response to well-defined stimuli. |
| DOI | 10.1097/TA.0000000000000845 |
| PMID | 26496102 |