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小島 光暁
Department Other, Other Position |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Discrete roles of intracellular phospholipases A2 in human neutrophil cytotoxicity. |
| Journal | Formal name：The journal of trauma and acute care surgery Abbreviation：J Trauma Acute Care Surg ISSN code：21630763/21630755 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 79(2),pp.238-46 |
| Author and coauthor | Mikami Saori, Aiboshi Junichi, Kobayashi Tetsuyuki, Kojima Mitsuaki, Morishita Koji, Otomo Yasuhiro |
| Publication date | 2015/08 |
| Summary | BACKGROUND:The role of calcium-independent phospholipase A2 (iPLA2), a component of the three major PLA2 families, in acute/chronic inflammatory processes remains elusive. Previous investigations have documented iPLA2-mediated respiratory burst of neutrophils (PMNs); however, the causative isoform of iPLA2 is unidentified. We also demonstrated that the iPLA2γ-specific inhibitor attenuates trauma/hemorrhagic shock-induced lung injury. Therefore, iPLA2γ may be implicated in acute inflammation. In addition, arachidonic acid (AA), which is primarily produced by cytosolic PLA2 (cPLA2), is known to display PMN cytotoxicity, although the relationship between AA and the cytotoxic function is still being debated on. We therefore hypothesized that iPLA2γ regulates PMN cytotoxicity via AA-independent signaling pathways. The study aim was to distinguish the role of intracellular phospholipases A2, iPLA2, and cPLA2, in human PMN cytotoxicity and explore the possibility of the presence of signaling molecule(s) other than AA. |
| DOI | 10.1097/TA.0000000000000730 |
| PMID | 26218692 |