コジマ　ミツアキ   小島　光暁    所属   その他 その他    職種   嘱託医師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Discrete roles of intracellular phospholipases A2 in human neutrophil cytotoxicity.
掲載誌名	正式名：The journal of trauma and acute care surgery 略　 称：J Trauma Acute Care Surg ISSNコード：21630763/21630755
掲載区分	国外
巻・号・頁	79(2),pp.238-46
著者・共著者	Mikami Saori, Aiboshi Junichi, Kobayashi Tetsuyuki, Kojima Mitsuaki, Morishita Koji, Otomo Yasuhiro
発行年月	2015/08
概要	BACKGROUND:The role of calcium-independent phospholipase A2 (iPLA2), a component of the three major PLA2 families, in acute/chronic inflammatory processes remains elusive. Previous investigations have documented iPLA2-mediated respiratory burst of neutrophils (PMNs); however, the causative isoform of iPLA2 is unidentified. We also demonstrated that the iPLA2γ-specific inhibitor attenuates trauma/hemorrhagic shock-induced lung injury. Therefore, iPLA2γ may be implicated in acute inflammation. In addition, arachidonic acid (AA), which is primarily produced by cytosolic PLA2 (cPLA2), is known to display PMN cytotoxicity, although the relationship between AA and the cytotoxic function is still being debated on. We therefore hypothesized that iPLA2γ regulates PMN cytotoxicity via AA-independent signaling pathways. The study aim was to distinguish the role of intracellular phospholipases A2, iPLA2, and cPLA2, in human PMN cytotoxicity and explore the possibility of the presence of signaling molecule(s) other than AA.
DOI	10.1097/TA.0000000000000730
PMID	26218692