阿部 結貴
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position |
|
Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | Possible Application of Ascites-infiltrating Gamma-delta T Cells for Adoptive Immunotherapy. |
Journal | Formal name:Anticancer research Abbreviation:Anticancer Res ISSN code:17917530/02507005 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 38(7),pp.4327-4331 |
Author and coauthor | Abe Yuki†, Kobayashi Hirohito*, Akizawa Yoshika, Ishitani Ken, Hashimoto Kazunori, Matsui Hideo |
Authorship | Lead author |
Publication date | 2018/07 |
Summary | BACKGROUND/AIM:Malignant ascites contain many tumour-infiltrating lymphocytes. γδ T cells with antitumour activity have attracted attention as effector cells in cancer immunotherapy. Vδ2+ T cells were cultured from peripheral blood mononuclear cells (PBMCs) and ascites-infiltrating lymphocytes (AILs) to compare the differences in response to 2-methyl-3-butenyl-1-pyrophosphate (2M3B1-PP) and zoledronate (Zol) as antigens in vitro.MATERIALS AND METHODS:To expand Vδ2+ T cells from PBMCs and AILs from 29 patients with cancer, these cells were cultured and subjected to analysis.RESULTS:The proliferation rate of Vδ2+ T cells was higher in both PBMCs and AILs when cultured with Zol than with 2M3B1-PP. Although Vδ2+ T cells show a higher rate of expansion in AILs compared to PBMCs, the number of mixed tumour cells in ascites was decreased when cultured with Zol.CONCLUSION:Vδ2+ T cells in AILs are cytotoxic to tumour cells in ascites and may be considered in adoptive immunotherapy. |
DOI | 10.21873/anticanres.12732 |
PMID | 29970569 |