イシグロ　タイチ   石黒　太一    所属   医学部 医学科（附属八千代医療センター）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Focal cortical high-frequency oscillations trigger epileptic spasms: confirmation by digital video subdural EEG.
掲載誌名	正式名：Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 略　 称：Clin Neurophysiol ISSNコード：13882457/13882457
掲載区分	国外
巻・号・頁	116(12),pp.2819-25
著者・共著者	Akiyama Tomoyuki, Otsubo Hiroshi, Ochi Ayako, Ishiguro Taichi, Kadokura Gemmu, Ramachandrannair Rajesh, Weiss Shelly K, Rutka James T, Carter Snead O
発行年月	2005/12
概要	OBJECTIVE:To localize high-frequency oscillations (HFOs) on the cortex during epileptic spasms using video subdural EEG and Multiple Band Frequency Analysis (MBFA).METHODS:Using video subdural EEG sampled at 1 kHz, we studied a 14-year-old boy with asymmetric epileptic spasms of possible left frontal origin. We identified HFOs, then analyzed and localized their distributions by MBFA. We correlated HFO distribution to clinical spasm intensity.RESULTS:Ictal subdural EEG recorded HFOs at 60-150 Hz lasting 0.3-4 s. MBFA showed extensive but noncontiguous distribution of HFOs predominantly over the left frontal and temporal regions. HFOs began and became quasiperiodic before manifestation of clinical spasms. As clinical spasms intensified, HFOs persisted in regions where they initiated subclinically but were of higher frequency and greater power than HFOs in other regions. We performed cortical resections over the left frontal and temporal regions with predominant HFOs. Six months after surgery, the patient remained seizure free.CONCLUSIONS:HFOs were present over the ictal onset zone during epileptic spasms. Periodic spasms in this patient had the characteristics of partial seizures.SIGNIFICANCE:We show that HFOs occurred over the cerebral cortex during epileptic spasms, and we suggest that these focal cortical HFOs triggered the spasms.
DOI	10.1016/j.clinph.2005.08.029
PMID	16253550