HOSHINO TAKAO    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Assistant Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Non-cardioembolic stroke/transient ischaemic attack in Asians and non-Asians: A post-hoc analysis of the PERFORM study.
Journal	Formal name：European stroke journal Abbreviation：Eur Stroke J ISSN code：(2396-9881)2396-9873(Linking)
Domestic / Foregin	Foregin
Volume, Issue, Page	4(1),pp.65-74
Author and coauthor	Hoshino Takao†, Sissani Leila, Labreuche Julien, Bousser Marie-Germaine, Chamorro Angel, Fisher Marc, Ford Ian, Fox Kim M, Hennerici Michael G, Mattle Heinrich P, Rothwell Peter M, Gabriel Steg Philippe, Vicaut Eric, Amarenco Pierre*
Publication date	2019/03
Summary	There was no difference in major adverse cardiovascular events risk between Asian and non-Asian populations (11.1% vs. 10.5%; p = 0.39). However, Asian patients were at significantly higher risk of intracranial haemorrhage (2.4% vs. 1.3%; hazard ratio (HR) 1.87; 95% confidence interval (CI) 1.34-2.60; p < 0.001) and major bleeding (5.4% vs. 4.1%; HR 1.30; 95% CI 1.04-1.61; p = 0.02). Stroke risk was significantly higher in Asian than in non-Asian populations among patients with lacunar stroke (7.4% vs. 4.5%; p = 0.02). In multivariable analysis, diastolic blood pressure (HR per 5 mm Hg 1.08; 95% CI 1.01-1.16; p = 0.03) and diabetes (HR 1.36; 95% CI 1.22-1.52; p < 0.001) were independent predictors of major adverse cardiovascular events for Asian and non-Asian patients, respectively.Conclusion: Compared with non-Asian patients, Asian patients had significantly higher risk of haemorrhagic events when given antiplatelet monotherapy for secondary prevention after non-cardioembolic stroke/transient ischaemic attack. Lacunar stroke and elevated diastolic blood pressure were more associated with recurrence risk in Asian patients.
DOI	10.1177/2396987318797245
PMID	31165096