HOSHINO TAKAO    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Assistant Professor
Article types	Case report
Language	English
Peer review	Peer reviewed
Title	Simultaneous development of acute disseminated encephalomyelitis and Guillain-Barre syndrome associated with H1N1 09 influenza vaccination
Journal	Formal name：Internal Medicine Abbreviation：Intern Med ISSN code：13497235
Volume, Issue, Page	51(12),pp.1595-1598
Author and coauthor	Hoshino Takaho†*, Uchiyama Yumiko, Ito Eiichi, Osawa Shunsuke, Ohashi Takashi
Authorship	Lead author,Corresponding author
Publication date	2012/06
Summary	A 36-year-old man was admitted to our hospital because of urinary retention and muscle weakness affecting all 4 limbs after receiving a H1N1 09 influenza vaccination. Magnetic resonance imaging demonstrated multiple lesions in his brain and spinal cord. Furthermore, nerve conduction study showed acute sensorimotor neuropathy, and anti-GM2 antibodies were detected in his serum. Based on the temporal association and exclusion of alternative etiologies, we made a diagnosis of acute disseminated encephalomyelitis (ADEM) and Guillain-Barré syndrome (GBS). To our knowledge, this is the first case of co-morbid ADEM and GBS after influenza vaccination with positive anti-ganglioside antibodies.
DOI	10.2169/internalmedicine.51.7132