TAKANO Noriyoshi
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Effect of GH Deficiency Caused by Nonfunctioning Pituitary Masses on Serum C-reactive Protein Levels.
Journal Formal name:Journal of the Endocrine Society
Abbreviation:J Endocr Soc
ISSN code:24721972/24721972
Domestic / ForeginForegin
Volume, Issue, Page 7(12),pp.bvad137
Author and coauthor Seki Yasufumi†*, Morimoto Satoshi, Bokuda Kanako, Watanabe Daisuke, Yamashita Kaoru, Takano Noriyoshi, Amano Kosaku, Kawamata Takakazu, Ichihara Atsuhiro
Publication date 2023/11
Summary CONTEXT:GH supplementation for GH deficiency (GHD) has been reported to decrease high-sensitivity C-reactive protein (hs-CRP), an inflammatory marker; however, the association between GHD and hs-CRP remains unclear.OBJECTIVE:We aimed to clarify the impact of impaired GH secretion due to pituitary masses on hs-CRP levels.METHODS:We retrospectively examined the association between GH secretion, assessed using GH-releasing peptide-2, and serum hs-CRP levels before and a year after the pituitary surgery in patients with nonfunctioning pituitary neuroendocrine tumor or Rathke cleft cyst.RESULTS:Among 171 patients, 55 (32%) presented with severe GHD (peak GH response to GH-releasing peptide-2 < 9 ng/mL). Serum hs-CRP levels were significantly higher in patients with severe GHD than in those without (P < .001) and significantly correlated with the peak GH (r = -0.50, P < .001). Multiple regression analyses showed that the peak GH significantly and negatively predicted hs-CRP levels (β = -0.345; 95% CI, -0.533 to -0.158) and the lowest quartile of the peak GH (<5.04 ng/mL) were significantly associated with increase in hs-CRP levels (exp [β] = 1.840; 95% CI, 1.209 to 2.801), after controlling for other anterior hormones and metabolic parameters. Postoperative change in the peak GH (N = 60) significantly predicted change in hs-CRP levels (β = -0.391; 95% CI, -0.675 to -0.108), independent of alterations in other anterior hormones and metabolic parameters.CONCLUSION:The inverse association between GH secretion and hs-CRP levels highlights the protective role of GH in the increase in hs-CRP.
DOI 10.1210/jendso/bvad137
PMID 38024646