イズモ　ワタル   IZUMO Wataru   出雲　渉    所属   医学部 医学科（東京女子医科大学病院）    職種   非常勤講師
論文種別	症例報告
言語種別	英語
査読の有無	査読なし
表題	A case of long-survival insulinoma with multiple neuroendocline tumour type 1 controlled by multimodal therapy.
掲載誌名	正式名：Journal of surgical case reports 略　 称：J Surg Case Rep ISSNコード：(2042-8812)2042-8812(Linking)
掲載区分	国外
巻・号・頁	2017(12),pp.rjx244
著者・共著者	SHIIHARA Masahiro†*, IZUMO Wataru, HIGUCHI Ryota, YAZAWA Takehisa, UEMURA Shuichiro, FURUKAWA Toru, YAMAMOTO Msakazu
担当区分	2nd著者
発行年月	2017/12
概要	Insulinomas with multiple neuroendocrine tumour type 1 (MEN1) sometimes have metachronous or recurrent tumours. However, the treatment for these tumours is controversial, and published reports regarding multimodal therapy for insulinomas are limited. We report a 73-year-old woman with recurrent insulinoma with MEN1 successfully controlled by multimodal therapy. She had several complications, and poor performance status. Her hypoglycaemia did not improve after 6-month octreotide LAR; as such, she underwent enucleation of the pancreatic tumour. Within 7 years after the first operation, she underwent four succeeding surgeries for recurrent tumours. Her medications during follow-up were octreotide-LAR and Everolimus. Insulinoma can be managed through various treatment options. Medical treatment includes octreotide-LAR and Everolimus, while surgical approach includes enucleation and pancreaticoduodenectomy. Some tumours, particularly those that are MEN1, can recur repeatedly. Thus, several treatments are needed to control them. We highlight the importance of multimodal therapy, including repeated surgery, for the control of the disease.
DOI	10.1093/jscr/rjx244
PMID	29250314