ヨシダ ケイタ   YOSHIDA Keita
  吉田 慶太
   所属   医学部 医学科
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Transcriptional regulation of a horizontally transferred gene from bacterium to chordate.
掲載誌名 正式名:Proceedings. Biological sciences
略  称:Proc Biol Sci
ISSNコード:1471-2954(Electronic)0962-8452(Linking)
掲載区分国外
巻・号・頁 283(1845),20161712頁
著者・共著者 Sasakura Yasunori†*, Ogura Yosuke, Treen Nicholas, Yokomori Rui, Park Sung-Joon, Nakai Kenta, Saiga Hidetoshi, Sakuma Tetsushi, Yamamoto Takashi, Fujiwara Shigeki, Yoshida Keita
発行年月 2016/12
概要 The horizontal transfer of genes between distantly related organisms is undoubtedly a major factor in the evolution of novel traits. Because genes are functionless without expression, horizontally transferred genes must acquire appropriate transcriptional regulations in their recipient organisms, although the evolutionary mechanism is not known well. The defining characteristic of tunicates is the presence of a cellulose containing tunic covering the adult and larval body surface. Cellulose synthase was acquired by horizontal gene transfer from Actinobacteria. We found that acquisition of the binding site of AP-2 transcription factor was essential for tunicate cellulose synthase to gain epidermal-specific expression. Actinobacteria have very GC-rich genomes, regions of which are capable of inducing specific expression in the tunicate epidermis as the AP-2 binds to a GC-rich region. Therefore, the actinobacterial cellulose synthase could have been potentiated to evolve its new function in the ancestor of tunicates with a higher probability than the evolution depending solely on a spontaneous event.
DOI 10.1098/rspb.2016.1712
文献番号 28003446